A controlled trial of the effect of milk basic protein (MBP) supplementation on bone metabolism in healthy menopausal women.
Aoe S, Koyama T, Toba Y, Itabashi A, Takada Y.
Department of Home Economics, Otsuma Women's University, 12 Sanban-cho Chiyoda-ku, 102-8357, Tokyo, Japan.
Milk has more beneficial effects on bone health than other food sources. Recent in vitro and in vivo studies have shown that milk whey protein, especially its basic protein fraction (milk basic protein, MBP), contains several components capable of promoting bone formation and inhibiting bone resorption. The object of this study was to examine the effect of MBP on the bone metabolism of healthy menopausal women. Thirty-two healthy menopausal women were randomly assigned to treatment with either placebo or MBP (40 mg per day) for 6 months. The bone mineral density (BMD) of the lumbar vertebrae L2-L4 of each subject was measured by dual-energy X-ray absorptiometry (DXA) at 0 and 6 months of treatment. Serum and urine indices of bone metabolism were measured at 0, 3 and 6 months. Twenty-seven subjects who completed the study in accordance with the protocol were included in the analysis. The mean rate of gain of lumbar BMD in the MBP group (1.21%) was significantly higher than in the placebo group (-0.66%, P=0.046). When compared with the placebo group, urinary cross-linked N-telopeptides of type-I collagen (NTx) were significantly decreased in the MBP group at 6 months, but no significant difference in serum osteocalcin was observed between the two groups. The urinary NTx excretion was found to be related to serum osteocalcin in the MBP group at 3 and 6 months, indicating that MBP maintained the balance of bone remodeling. These results suggested that MBP supplementation was effective in preventing bone loss in menopausal women and that this improvement in BMD may be primarily mediated through the inhibition of bone resorption while maintaining the balance of bone remodeling by MBP supplementation.
Los resultados sugieren que la suplementacion con Proteina básica de leche fue efectiva en la prevención de pérdida osea en mujeres menopausicas y que la mejora de la densidad osea fue principalmente mediada por la inhibicion de la resorcion osea.
Prevention of osteoporosis by foods and dietary supplements. Milk basic protein (MBP) increases bone mineral density in young adult women and perimenopausal women][Article in Japanese]
Itabashi A.
Saitama Center for Bone Research/Kubojima Clinic.
Milk has beneficial effects on bone health than other food sources. Recent in vitro and in vivo studies have shown that milk whey protein, especially its basic protein fraction (milk basic protein: MBP), contains components capable of promoting bone formation and inhibiting bone resorption. We tried to examine the effect of MBP on bone mineral density (BMD) and markers of bone metabolism in healthy young adult women and perimenopausal women. In the healthy young women study, we found that MBP increased BMD, by promoting bone formation and inhibiting bone resorption. In the healthy perimenopausal women study, we also found that MBP increased BMD, primarily by inhibiting bone resorption, while maintaining bone formation. Thus, bone remodeling balances become positive that leads to maintenance or increase of bone formation. MBP supplementation could be effective for bone health in a wide range of generation especially those who hate to drink milk.
La leche tiene efectos beneficos para la salud de los huesos , comparada con otras fuentes. Estudios recientes in vitro y en vivo, , han mostrado que la proteina de leche, especialmente su fraccion básica , contiene elementos capaces de promover la formacíon de hueso e inhibir la resorción.
Tratamos de analizar el efecto de las PB de Leche, en la densidad osea y otros marcadores del metabolismo oseo en mujres jóvenes adultas sanas, y en mujeres cercanas a la menopausia.
En el estudio efectuado sobre mujeres sanas, encontramos que las protienas básicas de leche, aumentan la densidad osea, por formacion de hueso e inhibición de la resorcion. En el otro estudio, tambien encontramos incremento en la masa osea pero solo por disminución de la resorción.