In Vino Veritas, ya en Amazon.com  

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  1. #1
    Usuari@ expert@ Avatar de sujal
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    marzo-2006
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    Guadalajara
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    Tratamiento artritis reumatoide con dietas vegetarianas

    Existe una línea de investigación centrada en dietas vegetarianas y ayunos, que demuestran la reducción en signos y síntomas de la artritis reumatoidea y potencialmente de otras enfermedades por auto aunticuerpos, las cuales involucran a muchas de las principales enfermedades no infectocontagiosas a nivel mundial.



    Rheumatoid arthritis treated with vegetarian diets

    Jens Kjeldsen-Kragh

    1 From the Department of Immunology and Transfusion Medicine, Ullevaal University Hospital, Oslo.
    2 Reprints not available. Address correspondence to J Kjeldsen-Kragh, Department of Immunology and Transfusion Medicine, Ullevaal University Hospital, N-0407 Oslo, Norway. E-mail: jens.kjeldsen-kragh@ioks.uio.no .


    Abstract

    The notion that dietary factors may influence rheumatoid arthritis (RA) has been a part of the folklore of the disease, but scientific support for this has been sparse. In a controlled, single-blind trial we tested the effect of fasting for 7–10 d, then consuming an individually adjusted, gluten-free, vegan diet for 3.5 mo, and then consuming an individually adjusted lactovegetarian diet for 9 mo on patients with RA. For all clinical variables and most laboratory variables measured, the 27 patients in the fasting and vegetarian diet groups improved significantly compared with the 26 patients in the control group who followed their usual omnivorous diet throughout the study period. One year after the patients completed the trial, they were reexamined. Compared with baseline, the improvements measured were significantly greater in the vegetarians who previously benefited from the diet (diet responders) than in diet nonresponders and omnivores. The beneficial effect could not be explained by patients' psychologic characteristics, antibody activity against food antigens, or changes in concentrations of prostaglandin and leukotriene precursors. However, the fecal flora differed significantly between samples collected at time points at which there was substantial clinical improvement and time points at which there were no or only minor improvements. In summary, the results show that some patients with RA can benefit from a fasting period followed by a vegetarian diet. Thus, dietary treatment may be a valuable adjunct to the ordinary therapeutic armamentarium for RA.

    A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: the effects on arthritis correlate with a reduction in antibodies to food antigens.



    I. Hafström, B. Ringertz1, A. Spångberg1, L. von Zweigbergk2, S. Brannemark1, I. Nylander, J. Rönnelid1, L. Laasonen3 and L. Klareskog1

    Department of Rheumatology, Karolinska Institutet at Huddinge University Hospital, Stockholm,
    1 Department of Rheumatology, Karolinska Institutet at Karolinska Hospital, Stockholm,
    2 The Unit for Preventive Nutrition, Karolinska Institutet at Novum, Huddinge, Sweden and
    3 Department of Radiology, Surgical Hospital, Helsinki University Central Hospital, Helsinki, Finland


    Abstract

    Objective. Whether food intake can modify the course of rheumatoid arthritis (RA) is an issue of continued scientific and public interest. However, data from controlled clinical trials are sparse. We thus decided to study the clinical effects of a vegan diet free of gluten in RA and to quantify the levels of antibodies to key food antigens not present in the vegan diet.

    Methods. Sixty-six patients with active RA were randomized to either a vegan diet free of gluten (38 patients) or a well-balanced non-vegan diet (28 patients) for 1 yr. All patients were instructed and followed-up in the same manner. They were analysed at baseline and after 3, 6 and 12 months, according to the response criteria of the American College of Rheumatology (ACR). Furthermore, levels of antibodies against gliadin and ß-lactoglobulin were assessed and radiographs of the hands and feet were performed.

    Results. Twenty-two patients in the vegan group and 25 patients in the non-vegan diet group completed 9 months or more on the diet regimens. Of these diet completers, 40.5% (nine patients) in the vegan group fulfilled the ACR20 improvement criteria compared with 4% (one patient) in the non-vegan group. Corresponding figures for the intention to treat populations were 34.3 and 3.8%, respectively. The immunoglobulin G (IgG) antibody levels against gliadin and ß-lactoglobulin decreased in the responder subgroup in the vegan diet-treated patients, but not in the other analysed groups. No retardation of radiological destruction was apparent in any of the groups.

    Conclusion. The data provide evidence that dietary modification may be of clinical benefit for certain RA patients, and that this benefit may be related to a reduction in immunoreactivity to food antigens eliminated by the change in diet.

    --------------------------------------------------------------------------------

  2. #2
    Usuari@ expert@
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    diciembre-2007
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    No me queda muy claro, pero creo que según la conclusión del estudio los resultados positivos se obtuvieron en los pacientes que siguieron la dieta vegana libre de gluten, no?

  3. #3
    Usuari@ expert@ Avatar de Kalkoven
    Fecha de ingreso
    diciembre-2006
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    Cita Iniciado por VeG Ver mensaje
    No me queda muy claro, pero creo que según la conclusión del estudio los resultados positivos se obtuvieron en los pacientes que siguieron la dieta vegana libre de gluten, no?
    Las enfermedades autoinmunes suelen mejorar con dietas veganas y mejorar aún más al retirar el gluten y, a veces, algunos otros alimentos de origen vegetal; a veces la recuperación es total o casi total, dependiendo del grado de avance de la enfermedad y de si se han producido ya deformaciones o lesiones importantes que afecten al funcionamiento de ciertos órganos, como el riñón; algunas de esas deformaciones o alteraciones funcionales no pueden corregirse porque el tejido afectado no puede reaparecer por arte de magia, pero sí puede evitarse o frenarse el avance; hay alguna enfermedad un poco especial, como la diabetes tipo I, en la que las células pancreáticas ya están destruidas y entonces sólo pueden reducirse hasta cierto punto los requerimientos de insulina con una dieta adecuada, pero nada más. La AR es de las que mejor responden, de hecho.

    Ya lo he comentado alguna vez en el foro y algún que otro forero, que debe de odiarme , lo ha experimentado en carne propia , jejejeje:

    http://www.forovegetariano.org/foro/...5&postcount=12

    http://www.forovegetariano.org/foro/...7&postcount=19

  4. #4
    Usuari@ expert@
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    diciembre-2007
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    Me pregunto si el gluten no será malo para todos?

    He leído que puede causar daño al vili del intestino: cuáles podrían ser las consecuencias si a largo plazo se acumula ese daño?

  5. #5
    Usuari@ expert@ Avatar de sujal
    Fecha de ingreso
    marzo-2006
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    Guadalajara
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    8.726
    Changes of faecal flora in rheumatoid arthritis during fasting and one-year vegetarian diet.(1994)

    Peltonen R, Kjeldsen-Kragh J, Haugen M, Tuominen J, Toivanen P, Førre O, Eerola E.

    Department of Medical Microbiology, University of Turku, Finland.

    The beneficial effect of a 1-yr vegetarian diet in RA has recently been demonstrated in a clinical trial. We have analysed stool samples of the 53 RA patients by using direct stool sample gas-liquid chromatography of bacterial cellular fatty acids. Based on repeated clinical assessments disease improvement indices were constructed for the patients. At each time point during the intervention period the patients in the diet group were then assigned either to a group with a high improvement index (HI) or a group with a low improvement index (LI). Significant alteration in the intestinal flora was observed when the patients changed from omnivorous to vegan diet. There was also a significant difference between the periods with vegan and lactovegetarian diets. The faecal flora from patients with HI and LI differed significantly from each other at 1 and 13 months during the diet. This finding of an association between intestinal flora and disease activity may have implications for our understanding of how diet can affect RA.

    PMID: 8019792 [PubMed - indexed for MEDLINE]
    http://www.ncbi.nlm.nih.gov/pubmed/8...ed.Pubmed_Resu

    --------------------------------------------------------------------------------------------------------------------

    Faecal microbial flora and disease activity in rheumatoid arthritis during a vegan diet.(1997)

    Peltonen R, Nenonen M, Helve T, Hänninen O, Toivanen P, Eerola E.

    Department of Medicine, Turku University Central Hospital, Finland.

    To clarify the role of the faecal flora in the diet-induced decrease of rheumatoid arthritis (RA) activity, 43 RA patients were randomized into two groups: the test group to receive living food, a form of uncooked vegan diet rich in lactobacilli, and the control group to continue their ordinary omnivorous diets. Based on clinical assessments before, during and after the intervention period, a disease improvement index was constructed for each patient. According to the index, patients were assigned either to a group with a high improvement index (HI) or to a group with a low improvement index (LO). Stool samples collected from each patient before the intervention and at 1 month were analysed by direct stool sample gas-liquid chromatography of bacterial cellular fatty acids. This method has proved to be a simple and sensitive way to detect changes and differences in the faecal microbial flora between individual stool samples or groups of them. A significant, diet-induced change in the faecal flora (P = 0.001) was observed in the test group, but not in the control group. Further, in the test group, a significant (P = 0.001) difference was detected between the HI and LO categories at 1 month, but not in the pre-test samples. We conclude that a vegan diet changes the faecal microbial flora in RA patients, and changes in the faecal flora are associated with improvement in RA activity.

    Se concluye que una dieta vegana cambia la flora fecal microbiana en los pacientes con AR (Artritis Reumatoide), y los cambios en la flora fecal se asocian con la mejora de actividad en la AR

    PMID: 9117178 [PubMed - indexed for MEDLINE]
    http://www.ncbi.nlm.nih.gov/pubmed/9...ed.Pubmed_Resu

  6. #6
    Usuari@ expert@ Avatar de sujal
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    marzo-2006
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    Guadalajara
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    Effects of a very low-fat, vegan diet in subjects with rheumatoid arthritis.(2002)

    McDougall J, Bruce B, Spiller G, Westerdahl J, McDougall M.

    St Helena Hospital, Deer Park, CA, USA.

    OBJECTIVE: To demonstrate the effects of a very low-fat, vegan diet on patients with rheumatoid arthritis (RA). DESIGN: Single-blind dietary intervention study. SUBJECTS AND STUDY INTERVENTIONS: This study evaluated the influence of a 4-week, very low-fat (approximately 10%), vegan diet on 24 free-living subjects with RA, average age, 56 +/- 11 years old. Outcome measurements: Prestudy and poststudy assessment of RA symptomatology was performed by a rheumatologist blind to the study design. Biochemical measures and 4-day diet data were also collected. Subjects met weekly for diet instruction, compliance monitoring, and progress assessments. RESULTS: There were significant (p < 0.001) decreases in fat (69%), protein (24%), and energy (22%), and a significant increase in carbohydrate (55%) intake. All measures of RA symptomatology decreased significantly (p < 0.05), except for duration of morning stiffness (p > 0.05). Weight also decreased significantly (p < 0.001). At 4 weeks, C-reactive protein decreased 16% (ns, p > 0.05), RA factor decreased 10% (ns, p > 0.05), while erythrocyte sedimentation rate was unchanged (p > 0.05).

    CONCLUSION: This study showed that patients with moderate-to-severe RA, who switch to a very low-fat, vegan diet can experience significant reductions in RA symptoms.

    Conclusión: Este estudio demostró que en los pacientes con moderada a grave RA que cambian a una dieta vegana de muy bajo contenido en grasa, pueden experimentar una reducción significativa de los síntomas en la AR.


    PMID: 11890437 [PubMed - indexed for MEDLINE]

  7. #7
    Usuari@ habitual
    Fecha de ingreso
    enero-2009
    Mensajes
    43
    Lo que se plantea para la artritis reumatoidea (y por que no para otras enfermedades autoinmunes) es ayuno mas dieta vegetariana.

    Acá hay otro abstract del tema:


    Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review.
    Müller H, de Toledo FW, Resch KL.
    Balneology and Rehabilitation Sciences Research Institute (FBK), Bad Elster, Germany. horst.mueller@medkur.de

    Clinical experience suggests that fasting followed by vegetarian diet may help patients with rheumatoid arthritis (RA). We reviewed the available scientific evidence, because patients frequently ask for dietary advice, and exclusive pharmacological treatment of RA is often not satisfying. Fasting studies in RA were searched in MEDLINE and by checking references in relevant reports. The results of the controlled studies which reported follow-up data for at least three months after fasting were quantitatively pooled. Thirty-one reports of fasting studies in patients with RA were found. Only four controlled studies investigated the effects of fasting and subsequent diets for at least three months. The pooling of these studies showed a statistically and clinically significant beneficial long-term effect. Thus, available evidence suggests that fasting followed by vegetarian diets might be useful in the treatment of RA. More randomised long-term studies are needed to confirm this view by methodologically convincing data.

    PMID: 11252685 [PubMed - indexed for MEDLINE]

    Los estudios muestran diferencias significativas despues de mas de tres meses del inicio del cambio de dieta con ayunos, en pacientes con artritis reumatoidea.
    Última edición por Krisnesh; 23-ene-2009 a las 15:08
    BABA NAM KEVALAM
    Dios es todo

 

 

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