Meat Consumption and Cancer Risk
Jeanine M. Genkinger, Anita Koushik*
Published: December 11,
2007
Jeanine M. Genkinger is at the Department of Oncology, Division of Cancer Genetics and Epidemiology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D. C., United States of America. Anita Koushik is at the Département de médecine sociale et préventive, Université de Montréal, and Axe Santé des populations, Centre de recherche du CHUM, Montreal, Quebec, Canada.
*To whom correspondence should be addressed. E-mail:
anita.koushik@umontreal.ca
The large international variation in incidence rates of cancer, together with findings from migrant studies, suggest that environmental factors such as diet are associated with cancer risk. The intake of meats, such as beef, varies 3-fold across the world—consumption is highest in developed countries (23 kg/capita) compared to less developed countries (6 kg/capita) [1]. Based on Richard Doll and Richard Peto's work in 1981, it has been estimated that approximately 35% (range 10%–70%) of cancer can be attributed to diet, similar in magnitude to the contribution of smoking to cancer (30%, range 25%–40%) [2].
Meat consumption in relation to cancer risk has been reported in over a hundred epidemiological studies from many countries with diverse diets. The association between meat intake and cancer risk has been evaluated by looking both at broad groupings of total meat intake, and also at finer categorizations, particularly intakes of red meat, which includes beef, lamb, pork, and veal, and also more specifically processed meats, which includes meats preserved by salting, smoking, or curing.
Although the association of cancer and meat intake may be partially explained by high-energy or high-fat (“westernized”) diets, of greater interest is a possible direct role of potentially carcinogenic compounds that are found in meats, including N-nitroso compounds, heterocyclic amines, or polycyclic aromatic hydrocarbons. N-nitroso compounds are broad-acting potent carcinogens in animal models [3] and include nitrosamines, which require metabolic activation to be converted to a carcinogenic form, and nitrosamides, which do not require activation. Similarly, heterocyclic amines are classified as mutagens and animal carcinogens [4–8]. These compounds and others present in meats (salts, nitrates, nitrites, heme iron, saturated fat, estradiol) have been theorized to increase DNA synthesis and cell proliferation, increase insulin-like growth factors, affect hormone metabolism, promote free radical damage, and produce carcinogenic heterocyclic amines [9–16], all of which may promote the development of cancer.