DHA y cáncer de próstata

Se ha publicado un estudio que muestra que el DHA inhibe el desarrollo del cáncer de próstata:

Bianchini F, Giannoni E, Serni S, Chiarugi P, Calorini L.
22 : 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis.
Br J Nutr. 2012 Dec;108(12):2129-37. doi: 10.1017/S0007114512000359.

http://www.ncbi.nlm.nih.gov/pubmed/22390897


Los resultados de dicho estudio contrastan con otro, publicado anteriormente, en el que se indicaba que las personas con más DHA tienen más posibilidades de sufrir cáncer de próstata:

Brasky TM, Till C, White E, Neuhouser ML, Song X, Goodman P, Thompson IM, King IB, Albanes D, Kristal AR
Serum Phospholipid Fatty Acids and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial.
Am J Epidemiol 2011 Apr 24. doi: 10.1093/aje/kwr027

http://aje.oxfordjournals.org/conten...wr027.abstract

Jack Norris ha escrito un interesante texto sobre el estudio más reciente. Él sigue considerando que los veganos menores de 60 años no deberían tomar suplementos de DHA a diario.

http://jacknorrisrd.com/?p=3531

mis padres ya se van tardando, es que no toman pescado todos los días, los pobrecicos.

Nuevo estudio sobre el DHA y el cáncer de próstata. En este caso se aprecia una relación entre los altos niveles de DHA y el cáncer de próstata.

Brasky TM, Darke AK, Song X, Tangen CM, Goodman PJ, Thompson IM, Meyskens FL Jr, Goodman GE, Minasian LM, Parnes HL, Klein EA, Kristal AR. Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial. J Natl Cancer Inst. 2013 Jul 10.

http://www.ncbi.nlm.nih.gov/pubmed/23843441


Jack Norris ha analizado este estudio. Él recomienda no tomar suplementos de DHA a diario, salvo en el caso de mayores de 60 años.

http://jacknorrisrd.com/dha-suppleme...ostate-cancer/

I'm skeptical...
it might be prudent...

"In summary, I’m skeptical that DHA causes prostate cancer, but if you are at high risk, it might be prudent to stick to the lower end of the daily recommendations until more is known."

Que manía con no dar la información completa :D

Aquí otro estudio que discute los estudios contradictorios:

Blood Level Omega-3 Fatty Acids as Risk Determinant Molecular Biomarker for Prostate Cancer, March 2013

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621295/

Algunas partes interesantes:

"Environmental factors and sources of fish oil have also been reported to contribute to prostate cancer development. Two studies have reported that environmental toxins such as polychlorinated biphenyls or methylmercury compounds, which are found in contaminated marine fish, when consumed in the diet, can disrupt androgen and estrogen balance that may be associated with prostate cancer development [131, 132]. "

"The studies included in the present analysis were carried out in western countries, where diets are generally not healthy; thus the results extracted can only be generally applied to the western population"

"Conclusion

In conclusion, this meta-analysis provided evidence that elevated blood levels of DPA are associated with decreased risk of developing prostate cancer. Elevated blood levels of EPA and DHA in combination are associated with increased risk of high-grade prostate tumor. Cautious interpretation of these results must be done, since prostate carcinogenesis is multifactorial, and the body's metabolism of n-3 PUFA is complex. "

Y otro estudio:

"The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-Mediated Akt-mTOR Signaling in Prostate Cancer Cells Expressing Mutant p53" June 2013

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691929/

"In summary, the present study shows that the ω3-PUFA DHA simultaneously induces autophagy and apoptosis in p53-mutant PC3 and DU145 cells by triggering mitochondrial ROS generation and that inhibition of Akt-mTOR signaling is involved in this process (Figure 5). These findings suggest that DHA may be beneficial to patients with p53-mutant prostate cancer and provide a strong rationale for the use of DHA in the treatment of prostate cancer."