cristianm
01-mar-2015, 00:26
Practicality of Intermittent Fasting in Humans and its Effect on Oxidative Stress and Genes Related to Aging and MetabolismTo cite this article:
Mr. Martin P Wegman, Mr. Michael Guo, Mr. Douglas M Bennion, Ms. Meena N Shankar, Mr. Stephen M Chrzanowski, Ms. Leslie A Goldberg, Ms. Jinze Xu, Ms. Tiffany A Williams, Dr. Xiaomin Lu, Dr. Stephen I Hsu, Dr. Stephen D Anton, Dr. Christiaan Leeuwenburgh, and Dr. Mark L Brantly. Rejuvenation Research. -Not available-, ahead of print. doi:10.1089/rej.2014.1624.
Online Ahead of Editing: December 29, 2014
Caloric restriction has consistently been shown to extend lifespan and ameliorate aging-related diseases. These effects may be due to diet-induced reactive oxygen species acting to upregulate sirtuins and related protective pathways, which research suggests may be partially inhibited by dietary antioxidant supplementation. Since caloric restriction is not sustainable long-term for most humans, we investigated an alternative dietary approach, intermittent fasting, which is proposed to act on similar biological pathways. We hypothesized that a modified intermittent fasting diet, where participants maintain overall energy balance by alternating between days of fasting (25% of normal caloric intake) and feasting (175% of normal) would increase expression of genes associated with aging and reduce oxidative stress and that these effects would be suppressed by antioxidant supplementation. To assess the tolerability of the diet and to explore effects on biological mechanisms related to aging and metabolism, we recruited a cohort of 24 healthy individuals in a double crossover, double-blinded randomized clinical trial. Study participants underwent two three-week treatment periods: intermittent fasting and intermittent fasting with antioxidant (Vitamins C and E) supplementation. We found strict adherence to study-provided diets and that participants found the diet tolerable, with no adverse clinical findings or weight change. We detected a marginal increase (2.7%) in SIRT3 expression due to the intermittent fasting diet, but no change in expression of other genes or oxidative stress markers analyzed. We also found that intermittent fasting decreased plasma insulin levels (1.01 uU/mL). Although our study suggests that the intermittent fasting dieting paradigm is acceptable in healthy individuals, additional research is needed to further assess the potential benefits and risks.
http://online.liebertpub.com/doi/abs/10.1089/rej.2014.1624
Las antiguas prácticas del yoga (el verdadero yoga, no el occidentalizado y gimnástico yoga, porqeu yoga significa UNIÓN CON DIOS), incluían los ayunos, para purificar el cuerpo y la mente......hoy, parece que se le está dando valor, pero con comprobaciones claras.
Esta investigación demuestra que la reducción del contenido calórico, a través de ayunos relativamente frecuentes, permiten prolognar la vida, mejorar la calidad de vida.
Es para tener en cuenta.
Mr. Martin P Wegman, Mr. Michael Guo, Mr. Douglas M Bennion, Ms. Meena N Shankar, Mr. Stephen M Chrzanowski, Ms. Leslie A Goldberg, Ms. Jinze Xu, Ms. Tiffany A Williams, Dr. Xiaomin Lu, Dr. Stephen I Hsu, Dr. Stephen D Anton, Dr. Christiaan Leeuwenburgh, and Dr. Mark L Brantly. Rejuvenation Research. -Not available-, ahead of print. doi:10.1089/rej.2014.1624.
Online Ahead of Editing: December 29, 2014
Caloric restriction has consistently been shown to extend lifespan and ameliorate aging-related diseases. These effects may be due to diet-induced reactive oxygen species acting to upregulate sirtuins and related protective pathways, which research suggests may be partially inhibited by dietary antioxidant supplementation. Since caloric restriction is not sustainable long-term for most humans, we investigated an alternative dietary approach, intermittent fasting, which is proposed to act on similar biological pathways. We hypothesized that a modified intermittent fasting diet, where participants maintain overall energy balance by alternating between days of fasting (25% of normal caloric intake) and feasting (175% of normal) would increase expression of genes associated with aging and reduce oxidative stress and that these effects would be suppressed by antioxidant supplementation. To assess the tolerability of the diet and to explore effects on biological mechanisms related to aging and metabolism, we recruited a cohort of 24 healthy individuals in a double crossover, double-blinded randomized clinical trial. Study participants underwent two three-week treatment periods: intermittent fasting and intermittent fasting with antioxidant (Vitamins C and E) supplementation. We found strict adherence to study-provided diets and that participants found the diet tolerable, with no adverse clinical findings or weight change. We detected a marginal increase (2.7%) in SIRT3 expression due to the intermittent fasting diet, but no change in expression of other genes or oxidative stress markers analyzed. We also found that intermittent fasting decreased plasma insulin levels (1.01 uU/mL). Although our study suggests that the intermittent fasting dieting paradigm is acceptable in healthy individuals, additional research is needed to further assess the potential benefits and risks.
http://online.liebertpub.com/doi/abs/10.1089/rej.2014.1624
Las antiguas prácticas del yoga (el verdadero yoga, no el occidentalizado y gimnástico yoga, porqeu yoga significa UNIÓN CON DIOS), incluían los ayunos, para purificar el cuerpo y la mente......hoy, parece que se le está dando valor, pero con comprobaciones claras.
Esta investigación demuestra que la reducción del contenido calórico, a través de ayunos relativamente frecuentes, permiten prolognar la vida, mejorar la calidad de vida.
Es para tener en cuenta.